血管紧张素转换酶和内皮素与糖尿病微血管病变的关系

Relationship between serum angiotensin converting enzyme and plasma endothelin levels and diabetic microangiopathy

目的 探讨血管紧张素转换酶 (angiotensinconvertingenzyme ,ACE)和血浆内皮素 (endothelin ,ET)水平与糖尿病微血管病变的关系。方法 用紫外分光光度法和直接放射免疫法测定 5 5例糖尿病患者和 30名正常人血清ACE和血浆ET水平。结果 糖尿病微血管病变患者血清ACE和血浆ET水平显著高于糖尿病无微血管病变患者 ,且随着糖尿病微血管病变的加重 ,血清ACE和血浆ET水平显著增高。糖尿病患者血清ACE和血浆ET水平呈显著正相关。

Objective To investigate the relationship between serum angiotensin converting enzyme(ACE) and plasma endothelin(ET) levels and diabetic microangiopathy.Methods Serum ACE and plasma ET levels were measured in 55 patients with diabetes mellitus and in 30 normal control subjects by radioimmunoassay and ultraviolet-spectrophotometry.Results Serum ACE and plasma ET levels in patients with diabetic microangiopathy were significantly higher than those in patients without diabetic microangiopathy.Along with the progression of diabetic microangiopathy,serum ACE and plasma ET levels were significantly elevated.There were significantly positive correlation between plasma ET and serum ACE levels in patients with diabetes mellitus.Conclusion These findings suggest that the increased serum ACE and plasma ET levels in patients with diabetic microangiopathy may be related to the development and progression of diabetic microangiopathy.