肝病患者血清促红细胞生成素含量分析及意义

The analysis and significance of EPO in liverish patient serum

探讨不同肝病患者血清EPO含量及病理生理意义。采用放免非平衡法检测 5 0例健康人和不同肝病患者血清EPO含量 ,并进行统计学处理。 18例肝硬化 (其中代偿期 8例 ,失代偿期 10例 )和 11例肝癌患者血清EPO含量明显高于正常对照组 ,P <0 0 0 1;失代偿期明显高于代偿期 ,P <0 0 1。肝硬化与肝癌相比亦有显著性差异 ,P <0 0 0 1。 2 5例急、慢性肝炎与正常对照组无显著性差异 ,P >0 0 5。

To explore the pathophysiologic significance of EPO concentration in various liverish patient's serum. The EPO concentration of 50 normal persons and 53 various liverish patients were detected by using non-balance radio immune assay, and the results were analysed with statistic method. The EPO concentrations of 18 cirrhosis patients (8 cases in compensatory phase; 10 cases in non-compensatory phase) were remarkably higher than thase, of normal control (P<0 001); There were remarkable difference between cirrhosis group and liver cancer group (P<0 001); the EPO concentrations of cirrhosis patients during non-compensatory phase were remarkably higher than those of the patients during compensatory phase, and there were no remarkable difference between acute and chronic hepatitis group and normal control group (P>0 05) The detection of EPO concentration can provide reference to various liverish pathophysiologic research further.