IH764-3对肝脏缺血再灌注损伤的保护作用

PROTECTIVE EFFECT OF SALVIA MILTIORRHIZAE ON ISCHEMIA-REPERFUSION INJURY IN RAT LIVER

目的 探讨中药丹参提取的有效单体IH764 3对肝脏缺血再灌注 (ischemiareperfusion ,I/R)损伤的作用。方法 通过预先对大鼠I/R模型腹腔注射IH764 3 ,经测定肝脏内ATP、AMP、ADP含量、肝细胞的能荷、血清谷丙转氨酶 (ALT)、谷草转氨酶 (AST)、碱性磷酸酶 (AKP)、谷胺酰转肽酶 (γ GT)等指标 ,并观察肝组织超微结构。结果 用药组较单纯I/R组肝组织内ATP含量高 ,肝脏功能损害轻 ,肝组织超微结构的损伤减轻。结论 IH764

Objective To study the efect of IH764-3 on ischemia-reperfusion (I/R) injury in rat liver. Methods Rats were divided into 3 groups, the control group was not subjected to ischemia and no treatment was given. I/R injury group was subjected to 40 minutes ischemia followed by reperfusion for 120 minutes. The IH764-3 group (40mg/kg) was administred at ischemia and reperfusion. Results In the IH764-3 group, sereum levels of ALT, AST, AKP and γ-GT were significantly lower than those in the I/R group. Energy charge level recovery was significantly higher with IH764-3 (P<0.05), hepatic ultrastructure was better preserved with IH764-3. Conclusion IH764-3 may be useful in the treatment of hepatic ischemia reperfusion injury