HBx在乙型肝炎病毒相关性肝癌形成与发展中的分子机理

THE MOLECULAR MECHANISM OF HBx IN THE CARCINOGENESIS OF HEPATITIS B VIRUS RELATED HEPATOCELLULAR CARCINOMA

目的 了解HBx基因在乙肝病毒相关性肝癌形成与发展中的分子机理。方法 综合国外近 5年的文献进行分析。结果 HBx具有促进细胞恶性转化、抑制受损DNA的修复、反式激活、抑制wtp5 3功能和抑制细胞凋亡等生物学功能。HBx可能通过直接致癌作用、抑制DNA的修复、抑制wtp5 3、干扰Fas/CD95系统和抑制Caspase 3活性等分子机理 ,诱发肝癌形成和促进肝癌发展。结论 HBx及其编码的蛋白HBxAg具有广泛的生物学功能 ,从多方面、多途径促进肝癌的形成和发展。

Objective To understand the molecular mechanism of HBx in the carcinogenesis of hepatitis B virus (HBV) related hepatocellular carcinoma (HCC).Methods The literatures published in the past 5 years which are mainly about HBx and hepatocellular carcinoma were reviewed. Results HBx had many functions, such as cell malignant transformation, inhibiting DNA repair, trans-activation, inhibiting p53 and apoptosis. These functions together with its Fas/Fas-L interfering and caspase-3 inhibiting could contribute to the carcinogenesis and development of HBV relatde HCC. Conclusion HBx has broad spectrum of biological functions, which contribute to the carcinogenesis and development of HBV related HCC.