狼疮性肾炎抗活化蛋白C的测定及意义

The detection of activated protein Cand in lupus nephritis its significance

目的 :探讨抗磷脂抗体和抗活化蛋白C(APCR)与狼疮性肾炎 (LN)的关系及APCR的可能形成原因。方法 :检测 33例LN和 37例无LN的系统性红班狼疮 (NLN) ,ELISA检测ACA -IgG、IgM、IgA、PTT -LA检测LA ,APTT±APC检测APCR。结果 :LN组APCR阳性率 5 7 6% ,明显高于NLN组 ( 32 4% ) ;LN组ACA(IgG、IgM )阳性率 42 4% ,明显高于NLN组 ( 18 9% ) ;APCR和IgG -ACA同时阳性LN的发生率 ( 7/ 7)明显高于APCR阳性而IgG -ACA阴性者( 12 / 2 4)。结论 :APCR和ACA在LN有较高的发生率 ,ACA引起的获得性APCR可能是LN的发病机制之一。

Objective:To explore the relationship between activated protein C(APCR),antiphospholipid antibodies and lupus nephritis(LN) and the possible reasons for APCR.Methods:APCR,ACA(lgG,lgM,lgA),LA,were measured with APTT±APC,ELISA,PTT-LA methods respectively in 33 LN patients and 37 SLE patients without LN(NLN).Results:The postive rates of APCR and ACA(IgG,IgM)in LN group were 57.6% and 42.4% respectively,which were significantly higher than that of NLN group(32.4% and 18.9% respectively).LN was more common in APCR and ACA-IgG positve patients(7/7) than in APCR positive but ACA-lgG negative patients (12/24).Conclusion:There were high prevalence of APCR and ACA in lupus nephritis.The acquired APCR induced by ACA may play an important role in LN's pathogenic mechanisms.