摘要
探讨特异性主动免疫疗法对慢性乙型肝炎的疗效。将 6 0例慢乙肝病例随机分成两组 ,待肝功能正常后 ,治疗组给予治疗用疫苗每月一次皮下注射 ,四个月一个疗程。治疗组 30例中 4例HBsAg阴转 ,9例HBeAg阴转 ,对照组只一例阴转 ,两组差异显著P <0 0 5。治疗组HBVDNA定量治疗前为 (0 0 3± 0 0 2× 10 5)拷贝 /ml,治疗结束时为 (0 0 0 7± 0 0 0 3× 10 5)拷贝 /ml,而对照组无明显变化 ,两组差异非常显著t =5 48。
To study the efficacy of specific active immunotherapy in the treatment of chronic hepatitis B. 60 patients diagnosed as chronic hepatitis B With normal liver functiion after being treated with conventional therapy were randomly assigned into two groups (treated group and control group). The treated group including 30 cases were treated with specific active immunotherapy for 4 months and the control group received a conventional treatment for 4 months. 4 of the 30 cases in the treated group were seroconverted from positive to negative against HBsAg, while none of the 30 cases in the control group became HBeAg negative. 9 of the 30 cases in the treated group became negative HBeAg, contrastively, only one case in the control group became HBeAg negative (P<0 05). Moreover, the HBVDNA copies was markedly reduced from (0.03±0.02×10 5)copies/ml to(0.007±0.003×10 5)copies/ml in the treated group as compared with the control group (t=5.48). From this preliminary clinical study, it is suggested that the specific active immunotherapy might has a benificial effect on chronic hepatitis B cases.
出处
《临床肝胆病杂志》
CAS
北大核心
2001年第3期159-160,共2页
Journal of Clinical Hepatology