普罗布考对脑梗塞患者一氧化氮调节作用的临床研究

The clinical study of probucol in cerebral infarction patients on NO regulating role

目的 :探讨普罗布考对脑梗塞患者一氧化氮 (NO)的调节作用。方法 :用Green改良法检测脑梗塞患者血清服药前和服药后的NO含量。结果 :脑梗塞患者血清NO水平明显高于正常值 (P <0 .0 5) ,服用普罗布考治疗 4周后患者NO水平恢复正常 ,临床疗效较常规治疗组明显提高 (P <0 .0 5)。结论 :普罗布考可调节脑梗塞患者NO水平、减轻缺血性损伤、促进神经功能恢复。

Objective: To explore Probucol played a regulating role in cerebral infarction patients by NO Methods: Using Green improving way, NO serum level of patients were detected,with taking drugs before and after. Results: NO level of patients were obviously higher than normal (P<0.05). But after taking Probucol 4 weeks,It restored. The therapeutic effect were higher than normal treatment group(P<0.05). Conclusion: Probucol can regulated NO level of cerebral infarction patients, decreased ischemia injury, and accelerated nervous function recovery.