更昔洛韦治疗新生儿巨细胞病毒感染疗效观察

The therapeutic effect of ganciclovir on neonatal human cytomegalovirus infections

目的 :探讨更昔洛韦治疗新生儿巨细胞病毒 (HCMV)感染疗效。方法 :将 50例HCMV感染新生儿随机分两组 ,治疗组 2 5例 ,对照组 2 5例。治疗组用更昔洛韦 ,每次 5mg/kg ,每日 2次 ,连用14d。对照组用干扰素 ,每次 1× 10IU ,每日 1次 ,连用 7d。二组均用FQ -PCR法检测血HCMVDNA判断疗效。结果 :更昔洛韦组用FQ -PCR法检测HCMVDNA转阴率 76% ,干扰素组转阴率 4 8% ,X =4 .16(P <0 .0 5) ,具有显著差异。结论 :本组资料表明更昔洛韦治疗新生儿HCMV感染疗效优于干扰素 ,但应注意其可引起白细胞和血小板减低。

Objective:To investigate the therapeutic effect of ganciclovir on neonatal human cytomegalovirus (HCMV) infections. Methods: 50 cases of neonatal HCMV infections were divided into 2 groups. Treatment group (n=25) was treated with granciclovir 5mg kg t , iv, Bid, for 14d. Control group was treated with interferon 1×10 IU, im, qd, for 7d. The serum HCMV-DNA was measured by fluorescent quantitative pay merase claim reaction (FQ-PCR) method. Result:After treatment, the HCMV-DNA negative rate (76%) in ganciclovir group was higher than that in interferon group (48%) (X = 4.16, P<0.05). Conclusion: It is more effective with ganciclovir than with interferon in ereating neonatal HCMV infections, but we should pay attention to the eoxicity with granciclovir, including neotropenia and throm bocy to penia.