川芎嗪治疗瘢痕疙瘩的临床研究

CLINICAL STUDY OF THE EFFECT OF TETRAMETHYLPYRAZINE ON KELOID

目的 :研究川芎嗪治疗瘢痕疙瘩的疗效。 方法 :采用自身对照 ,以川芎嗪局部注射瘢痕疙瘩 3个月 ,测定瘢痕组织硬度的变化及羟脯氨酸的含量。 结果 :1用药组瘢痕硬度较用药前明显降低 (P<0 .0 1) ,而对照组瘢痕硬度无明显变化 (P>0 .0 5 )。 2用药瘢痕组织羟脯氨酸含量明显低于对照组 (P<0 .0 1)。 结论 :川芎嗪能抑制瘢痕疙瘩成纤维细胞胶原的合成 ,使瘢痕软化。川芎嗪治疗瘢痕疙瘩有肯定的临床意义。

Objective:To study the effect of Tetramethylpyrazine(TMP)on keloid. Methods:Using self control,the keloids were treated injection of TMP for 3 months.The hardness of keloids before and after treatment and the content of hydroxy proline (HP)were measured. Results:①The treated keloids after treatment were softer than those before treatment (P<0 01).However,the hardness of control group showed no statistical difference between before and after treatment (P>0 05) ②The content of HP of treated group were apparently lower than those of control group (P<0 01). Conclusion:TMP can inhibit the collagen synthesis of keloid derived fibroblasts and soften keloids.It is thought that the TMP is valuable for treating keloids. [