摘要
目的 :检测重组人可溶性血管内皮细胞生长抑制因子 (VEGI)的抗肿瘤活性。 方法 :检测重组人可溶性 VEGI对建株人脐静脉内皮细胞 (ECV 30 4)、新生牛主动脉内皮细胞 (BAEC)增殖抑制的活性以及对荷 S180肉瘤小鼠的疗效。 结果 :重组人可溶性 VEGI可以直接抑制 ECV30 4、BAEC的增殖 ,强烈抑制 S180肉瘤生长并延长 S180腹水瘤小鼠的寿命。结论 :重组人可溶性 VEGI可通过抑制新生血管形成用于肿瘤治疗。
Objective: To detect anti tumor activity of the recombinant human soluble vascular endothelial growth inhibitor (VEGI). Methods: The recombinant human soluble VEGI was tested for its inhibition on proliferation of the established human umbilical vein endothelial cells (ECV304) and new born bovine aortic endothelial cells(BAEC).Mice bearing transplanted S180 sarcoma and mice with ascites S180 were treated with the recombinant human soluble VEGI. Results: The recombinant human soluble VEGI showed markedly inhibitory effect on the proliferation of endothelial cells and the growth of S180 sarcoma.It also prolonged the life time of mice with ascites S180. Conclusion: The recombinant human soluble VEGI may be applied for cancer therapy by anti angiogenesis. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2001年第7期639-641,共3页
Academic Journal of Second Military Medical University
基金
"九五"国家科技攻关医药生物关键技术重点项目 ( 96-C0 2 -0 1-12 )
