35年(1964～1999年)大肠癌住院病例的动态分析

Dynamic analysis of hospitalized colorectal cancer patients in 35 years (1964～1999)

目的 动态分析 35年来大肠癌临床流行病学特征的变迁。方法 应用我院 196 4～ 1999年大肠癌住院病例 375 1例分析发病情况、发病年龄、性别及部位构成的变化。结果 从 196 4年至 1999年 ,大肠癌病例数明显上升 ,其中男性稍多 ,但女性构成比呈上升趋势 ,男女比从 6 0年代的 1.6∶1下降至 90年代的 1.3∶1;发病年龄高峰后移 ,中位发病年龄由 48岁上升至 5 3岁 ;发病部位直肠癌为主 ,占 70 % ,但呈下降趋势 ,自 90年代以前的 74%下降至 90年代的6 7% ;而同期呈明显增加的是右半结肠癌和乙状结肠癌。结论 大肠癌发病呈上升趋势 ,女性患者比例增加 ,发病年龄高峰后移 ,发病部位仍以直肠为主 。

Objectives To analyze the dynamic changes in clinico-epidemiological features of colorectal cancer from 1964 to 1999. Methods 3 751 hospitalized patients with colorectal cancer during 1964～1999 in Tumor Hospital of SUMS were included for analysis of clinico-epidemiological features including incidence, sex ratio, peak age and site distribution. Results From 1964 to 1999, hospitalized colorectal cancer patients in Tumor Hospital increased significantly. 58.2% of patients were male and the ratio of female patients increased with time. The ratio of male to female fell from 1.6:1 in 1960s to 1.3:1 in 1990s. The median peak age of colorectal cancer increased from 48 in 1960s to 53 in 1990s. The percentage of rectal cancer decreased from 74% before 1990s to 67% in 1990s, although it accounted 70% of all cases. Cancer in right half colon and sigmoid colon increased. Conclusion Incidence of colorectal cancer is increasing. Female constitution is increasing. Peak age of colorectal cancer is also increasing. Site distribution has a tendency of moving to the proximal large bowel, although rectal cancer still accounts for the majority (70%).