窒息新生儿32例胃排空及胃动素、一氧化氮变化的临床观察

Gastric emptying,motilin and Nitric oxide in neonates with asphyxia.

目的 探讨窒息对新生儿胃排空功能的影响。方法 采用B型实时超声显像法观察 32例窒息新生儿餐后胃窦纵切面积的动态变化 ,并检测餐前及餐后半小时血中胃动素、一氧化氮 (NO)水平 ,同时与 10例正常新生儿比较。结果 与正常组相比 ,轻度窒息组 10 %、5 0 %、10 0 %胃排空时间及餐前、餐后胃动素、NO水平无明显变化 ,差异无显著性意义 (均为P >0 0 5 ) ,而重度窒息组胃排空时间明显延长 ,餐前、餐后胃动素、NO水平明显升高 ,差异有极显著意义 (均为P <0 0 1)。结论 重度窒息新生儿胃排空延迟 ,与胃动素、NO的变化有关。

Objective To investigate the impact of asphyxia on neonatal gastric emptying.Methods The dynamic changes of the antral cross sectional area after meal were osberved by means of type-B ultrasonography and the levels of blood motilin and nitric oxide before and half an hour after meal were measured in 32 neonates with asphyxia and 10 normal neonates who were served as controls.Results There were no significant difference in 10%,50%,100%gastric emptying time and the levels of motilin and nitric oxide before and after meal between the slightly asphyxic neonates and the normal neonates(P>0 05).However,in the neonates with severe asphyxia,the gastric emptying time were longer and the levels of motilin and nitric oxide before and after meal were higher significant than those in the normal group(P<0 01).Conclusion The gastric emptying function decreased in the severely asphyxic neonates,which was associated with the changes of the motilin and nitric oxide levels.