乙型肝炎感染模式及甲胎蛋白检测与肝癌的关系

Relationship between infective patterns of hepatits B and a Fetal protein detection and hepatic cancer

目的 :了解乙型肝炎感染模式及甲胎蛋白检测与肝癌的关系。方法 :对 64例已确诊的肝病 (包括肝癌、肝硬化、乙型肝炎 )患者同时用ELISA法进行乙型肝炎五项血清学标志物及用RIA法进行AFP检测。结果 :3 7例肝癌患者中 ,HB sAg、HBeAg、抗HBc三项阳性者 10例 ,HBsAg、抗HBe、抗HBc三项阳性者 12例 ,HBsAg、抗HBc两项阳性者 12例 ;在 12例HBsAg、抗HBe、抗HBc三项阳性中 ,AFP全部 >40 0ng/ml。结论 :以乙型肝炎HBsAg、抗 -HBe、抗 -HBc阳性和HBsAg、HBeAg、抗HBc阳性发生肝癌的危险性最大 ;HBsAg、HBeAg、抗HBc阳性次之 ;其它感染模式发生肝癌的危险性很小。若以上几种模式同时伴有AFP值的持续升高 。

Objective To study the relationship between infective patterns of hepatitis B and α-fetal protein detection and hepatic cancer.Methods Sixty-three patients with hepatic diseases including hepatic cancer,cirrhosis and hepatitis B were determined the 5 serological markers with ELISA and AFP with RIA. Results In 37 cases of hepatic cancer,there were 10 cases showing positive HBsAg,HBeAg and anti HBc(Pattern Ⅰ),12 cases showing positive HBsAg,anti-HBe and anti-HBc(Pattern Ⅱ),and 12 cases showing positive HBsAg and anti-HBc(Pattern Ⅲ).In pattern Ⅱ ,AFP>400 ng/ml. Conclusions The risk of hepatic cancer is the highest in pattern Ⅱ and Ⅲ,the second highest in pattern Ⅰ and the lowest in other infection patterns.If any of the three patterns is combined with continuous increase of AFP,it indicates carcinomatous change in hepatic cells. [