摘要
目的 :观察纳络酮治疗肺性脑病的安全性及有效性。方法 :10 0例肺性脑病患者随机分为 A、B两组 ,A组 5 0例 ,除综合治疗外 ,加用纳络酮 0 .4m g～ 0 .8mg+生理盐水 2 0 mg,静脉滴注 ,30 m in～ 10 0 min一次 ;B组 5 0例患者仅给予综合治疗。结果 :A组患者经治疗后 48例痊愈 ,2例死亡 ;B组经单纯综合治疗 36例痊愈 ,14例死亡。两组疗效有显著差异 (P<0 .0 5 )。研究显示纳络酮可有效解除肺性脑病患者的呼吸抑制、促醒并明显降低其死亡率 ,且无明显毒副作用。结论 :纳络酮治疗肺性脑病安全有效 。
Objective:The purpose of this study was to evaluat the efficacy and safety of naloxone in the treatment of pulmonary encephalopathy.Methods:One hundred patients with pulmonary encephalopathy were randomly divided into two groups (A,B).Fifty patients in group A were treated with naloxone 0.4 mg～0.8 mg+N·S 20 mg,iv,per 30～100 mintues a time,in addition to combined treatment;and fifty patients in group B were given combined treatment only.Results:48 cases in group A were cured,the other 2 cases died.Patients in group B,36 cases were cured,14 cases died.The therapeutic effect between them was significant different( P <0.05).Naloxone can waken patients with pulmonary encephalopathy reduce respiratory inhibition and casefatality rate without side-effect.Conclusion:Naloxone is a effective reliable and safe durg for pulmonary encephalopathy.
出处
《山西临床医药》
2001年第7期505-506,共2页
Shanxi Clinical Medicine
