先天愚型患者红细胞Cu—Zn SOD活性的变化

The Variation of Erythrocyte Superoxide Dismutase Activity in Down's Syndrome

本文报告8例先天愚型红细胞Cu—Zn SOD活性(以正常儿童和非先天愚智能发育不全患儿为对照)的测定结果。证明先天愚型患儿SOD活性为正常儿童的1.7倍(p<0.01),是非先天愚智能发育不全患儿的2.1倍(p<0.001)。

Erythrocyte superoxide dismutase activity in 8 patients with Down's syndrome aged 2—18 years were measured. Two control groups were studied. The first consisted of mentally retarded children other than Down's syndrome. The second group were normal children. The results revealed that Drwn's syndrome patients have more, (on average, 70—100％)SODA in the erythrocytes than both control gooups. The resultS were consistent with that of Sinet et al, which demonstrated a gene dosage effect in trisomy 21.