高血压病及合并脑卒中患者血浆纤维连接蛋白的测定

Plasma Fibronectin in Essential Hypertension , Stroke and Normal subjects

本文应用ELISA法,观察了24例高血压病,26例同时患有脑卒中患者血浆纤维连接蛋白(Fibronectin,FN)含量的变化,同时观察了31例正常人对照。结果发现高血压病(EH),及伴脑梗塞组血浆FN显著高于正常人组(P<0.001)及EH伴脑出血组(P<0.02)。但EH组与EH伴脑梗塞组血装FN水平相当(P>0.05)。脑出血组有6例血浆FN水平极低者,其中4例死亡,1例同时患有高心病、心衰,另一例短期内恢复。动态观察脑出血病人血浆FN变化,可能对其病情判断有帮助。

Plasma fibronectin was determined in 31 normal adults and in50 pqtitents lnly with essentiat ht pertension(EH), 15patients with EH and cerebral haemorrhage, and the other 11 with EH and cerebral thrombosis. The mean values of the protein in EH and EH+cerebral thrombosis were significant higher than that in nomal controls and EF+cerebral haemorrhage (P<0.001,0.02 respec tively). Fibronectin levels in EH patients did not iffer tfrom that in EH+cerebral thrombosis. There were 6 patiens im EH+cerebral haemorrhage with very low plasma fibronectin. Its almostly could not be measrued. four of the patients died in 48 hours.