4Bumb A, Diederich N, Beyenburg S. Adding topiramate to valproate therapy may cause reversible hepatic failure [ J ]. Epileptic Disord, 2003, 5(3) :157-159.
5Chitturi S, George J. Hepatotoxicity of commonly used drugs:nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs[J]. Semin Liver Dis, 2002, 22 (2) :169-183.
6Longin E, Teich M, Koelfen W, Konig S. Topiramate enhances the risk of valproate-associated side effects in three children [ J ].Epilepsia, 2002, 43 (4) : 451-454.
8Pylvanen V, Pakarinen A, Knip M, Isojarvi J. Insulin-related metabolic changes during treatment with valproate in patients with epilepsy[J]. Epilepsy Behav, 2006 , 8 (3): 643-648.
9Pavone A, Cardile V. An in vitro study of new antiepileptic drugs and astrocytes[J]. Epilepsia, 2003, 44 (10) : 34-39.
10Tong V, Teng XW, Chang TK, Abbott FS. Valproic acid Ⅱ:effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes [ J ]. Toxicol Sci, 2005, 86(2): 436-443.