子宫内膜异位症患者外周血单个核细胞白细胞介素6的检测——附35例资料分析

Increased production of IL 6 by peripheral blood mononuclear cells from patients with endometriosis:analysis of 35 cases

目的：探讨子宫内膜异位症患者外周血中白细胞介素６（ＩＬ－６）水平变化对异位病灶组织的作用。方法：用生物学检测法测定子宫内膜异位症患者（３５例）、健康成年女性（２８名）外周血中单个核细胞（包括淋巴细胞及单核细胞）所产生的ＩＬ－６的活性。结果：子宫内膜异位症患者外周血中单个核细胞产生ＩＬ－６为（１１２±２５）ｋＵ／Ｌ，与对照组（７０±１１）ｋＵ／Ｌ比较，有非常显著性差异（Ｐ＜０．０１）。结论：子宫内膜异位症患者体内存在ＩＬ－６高水平状态，由此造成的免疫功能改变可能对子宫内膜异位症的异位组织生长有促进作用。

Objective:To investigate the production of interleukin 6(IL 6) by peripheral blood mononuclear cells(PBMC)from patients with endometriosis Methods:Production of IL 6 by PBMC stimulated by phyto hemagglutinin(PHA) was measured using biological activity assay Results:IL 6 produced by PBMC in patients with endometriosis was significantly higher than that in control[(112±25) kU/L vs(70±11)kU/L, P <0 01] Conclusion:Overproduction of IL 6 can augment the growth of endometriosis cells