间羟胺激发试验对鉴别哮喘与慢性支气管炎的临床价值

The clinical value of metaraminol provoking test in distinguishing asthma and chronic bronchitis

目的：探讨间羟胺激发试验区别哮喘和慢性支气管炎（慢支）气道高反应性的应用价值。方法：组胺激发试验阳性的哮喘和慢支患者吸入浓度递增（０．０８～１０ｇ／Ｌ）的间羟胺，阳性者吸入酚妥拉明溶液后，再次行间羟胺激发试验。结果：７３％哮喘间羟胺激发试验阳性，慢支患者均阴性，酚妥拉明不能阻断间羟胺激发试验阳性者。结论：哮喘和慢支的气道高反应性的机制不同，间羟胺可有效地区别气道高反应性是哮喘抑或慢支引起的。

Objective:To evaluate the clinical value of metaraminol inhaled challenge in distinguishing in asthma from chronic bronchitis Methods:30 cases with airway hyperresponsiveness(AHR)to histamine,including 15 patients with asthma and 15 cases with chronic bronchitis,underwent increasing dosage(0 08～10 g/L)of metaraminol challenge 10 cases with AHR to metaraminol inhaled phentolamine before receiving next metaraminol challenge Results:Metaraminol challenges were positive in 73% of asthma and in none of chronic bronchitis Phentolamine did not improve AHR to metaraminol Conclusion:There is a different mechanism of AHR in asthma and chronic bronchitis Metaraminol provoking test is useful for distinguishing AHR in asthma from those caused by chronic bronchitis