摘要
目的:探讨小剂量胺碘酮对急性心肌梗死(AMI)并高危快速型心律失常患者的临床疗效。方法:105例AMI并高危快速型心律失常患者随机分为2组;在AMI常规治疗的基础上,胺碘酮组:0.2g、每天3次,起效后减至每天1次口服,疗程3年。美托洛尔组:25~50mg,每天2次口服,疗程同上。结果:住院期间治疗组心肌梗死后心绞痛发生次数、静脉硝酸甘油剂量、用镇痛药次数均较美托洛尔组少(P<0.05,P<0.01),而左心室射血分数(LVEF)、左心室短轴缩短率(FS)、二尖瓣快速充盈期和心房收缩期二尖瓣血流速度(E/A)均较美托洛尔组高(P<0.05,P<0.01);泵衰竭发生率较美托洛尔组少(P<0.05)。随访3年,胺碘酮组发生不稳定型心绞痛、再发心肌梗死、心力衰竭均较美托洛尔组少(P<0.05)。结论:小剂量胺碘酮治疗AMI并高危快速型心律失常患者作用可靠、不良反应轻微,可作为预防再发梗死、改善预后的抗心律失常药物。
Objective:To investigate the efficacy of low dosage of amiodarone in treating acute myocardial infarction(AMI)with arrhythmia Methods:105 cases of AMI with arrhythmia were randomly assigned into two groups In the base of routine AMI therapy,patients in amiodarone group were treated with amiodarone 0 2 g three times daily for 5 to 7 days,followed by 0 2 g once daily for three years Patients in control group were given 25 mg to 50 mg of metoprolol twice daily for three years Results:During in hospital period,the number of attacks of post infarction angina,consumption of intravenous nitroglycerin,and times of analgesics required in amiodarone group decreased significantly than that of control( P <0 05) LVEF,SF,and E/A in amiodarone group increased significantly than that of control group( P <0 05) During the subsequent follow up,the attacks of unstable angina,recurrent myocardial infarction,and heart failure in amiodarone group were significantly fewer Conclusion:Low dosage of amiodarone is effective in treating AMI complicated with tachyarrhythmia with mild adverse effects It can prevent recurrent infarction and improve prognosis
出处
《新医学》
1999年第2期75-77,共3页
Journal of New Medicine
关键词
心肌梗死
心律失常
生存率
胺碘酮
治疗
Myocardial infarction Arrhythma Survival rate Amiodarone