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细胞凋亡基因Fas/FasL的免疫学作用

The Immunological Function of Apoptosis Gene Fas/ FasL
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摘要 本文简介了有关细胞凋亡相关基因Fas/FasL的基因与蛋白结构,信号传导途径以及它在细胞凋亡中的作用,并讨论了它在免疫学上的功能以及与自身免疫性疾病的关系。 This article introduced the apoptosis genes Fas/FasL including the structure of their genes and proteins, the path of their signal transmission and how they worked on apoptosis. Then the immunological functions and relationships with some self-immune diseases of Fas/FasL were discussed.
作者 朱建明
机构地区 中山大学生命科学学院
出处 《中山大学研究生学刊（自然科学与医学版）》 2000年第1期46-51,共6页 Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)
关键词 FAS/FASL 细胞凋亡 免疫学作用 信号传导途径 细胞损伤 程序性细胞死亡 Fas/FasL, Apoptosis, Immune
分类号 Q255 [生物学—细胞生物学] Q939.91 [生物学—微生物学]
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参考文献10

  • 1Watanabe-fukunage R,,Brannan C I,Itoh N et al.The cDNA structure, expression and chromosomal assignment of the mouse fas antigen[].J Immunol.1992
  • 2Tartaglia L A,Ayres T M,Wong G H W et al.A novel domain within the 55kd TNF receptor signals cell death[].Cell.1993
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  • 6Martin S J,Green D R.Protease activation during apoptosis: Death by a thousand cuts?[].Cell.1995
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  • 8Rothstein T L,Wang J K M,Panka D J et al.Protection against fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells[].Nature.1994
  • 9Griffith T S,Burnner T,Fletcher S M et al.Fax lignad-induced apoptosis as a mechanism of immune privilege[].Science.1995
  • 10Cheng J,Zhou T,Liu C et al.Protection from fas-mediated apoptosis by a soluble form of the fas molecule[].Science.
中山大学研究生学刊（自然科学与医学版）
2000年 第1期

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