重组粒细胞集落刺激因子在儿童急性白血病中的应用

Application of rhG-CSF in children's acute leukemia

目的 :研究用重组粒细胞集落刺激因子 (rhG CSF)对强烈化疗后急性白血病患儿中性粒细胞严重低下的治疗作用。方法 :比较强烈化疗后急性白血病患儿用重组粒细胞集落刺激因子组 (n =136 )与对照组 (n =6 5 )中性粒细胞绝对值 (ANC)的降低时间、感染发生率及严重程度。结果 :ANC≥ 0 .5× 10 9/L的时间 ,治疗组比对照组明显者缩短 (P <0 .0 5 ) ,感染发生率和严重程度明显亦降低。结论 :应用重组粒细胞集落刺激因子后可使粒细胞计数和功能恢复快 ,感染发生率和严重程度减少 ,并可减少经济负担。

Purpose:To study the therapeutic effect of rhG-CSF upon the severe hypogranulocytosis of children with acute leukemia after intensive chemotherapy. Methods:After intensive chemotherapy, the comparison between the group with rhG-CSF treatment ( n =136) and the control group ( n =65) was made on the ANC dropping time, the incidence rate and the degree of severity of the infection.Results:The period of ANC ≥0.5×109/L was shorter in the group with rhG-CSF treatment than that in the control group ( P <0.05). A significant decrease was also shown in the incidence rate and the severity of infection in the former group. Conclusions:With the rhG-CSF treatment, the blood granulocyte count and its function recover quickly. The incidence and the severity of infection decreased and the family expensive are also relieved.