吉西他滨治疗14例晚期胰腺癌

Treatment with gemcitabine in 14 cases with advanced pancreatic cancer

目的 :研究吉西他滨 (gemcitabine)治疗晚期胰腺癌的疗效。方法 :14例进展期胰腺癌患者 ,用吉西他滨第 1周 80 0mg/m2 ,第 2周 10 0 0mg/m2 ,第 3周 12 0 0mg/m2 ,每周 1次 ,每次以 0 .9%生理盐水 10 0ml溶解后静脉滴注 ,30分钟滴完 ,连续 3周 ,随后休息 1周为一疗程 ,以后每 4周重复一次 ,共 6个疗程。结果 :疼痛缓解有效率为6 4% (9/ 14) ,延长了中位生存期 ,平均为 8.7个月。临床受益反应为 43%。吉西他滨治疗晚期胰腺癌能显著改善晚期胰腺癌患者的临床症状 ,减轻疼痛。生活质量有明显提高。结论 :吉西他滨可作为晚期胰腺癌综合治疗时首选的化疗药物。

Purpose:To observe the effects of chemotherapy with gemcitabine in advanced pancreatic cancer.Methods:Fourteen patients with advanced pancreatic cancer were treated with gemcitabine in doses of 800 mg/m2 first week, 1 000 mg/m2on second week and 1 200 mg/m2 on third week.The drug was diluted in 100ml of normal saline and administered intravenously over 30 minutes.Gemcitabine was administered once a week for 3 consecutive weeks out of every 4 weeks, a cycle defined as one 4-week period, total 6 cycles.Results:Nine patients of 14 had an improvement in pain. Median survival duration was 8.7 months and clinical beneficial response was 43%. Clinical symptoms were markedly improved in patients with advanced-stage pancreatic cancer. Severity of pain, analgesic consumption, patients' QOL and survival period were greatly improved. Conclusions:It is suggested that gemcitabine be a favorable, helpful chemotherapy in advanced pancreatic cancer.