阵发性心房颤动患者血浆TXB_2、6-K-PGF_(1α)、GMP140浓度变化的研究

The changes of plasma TXB_2、6-K-PGF_(1α)、GMP140 in patients with paroxysmal atrial fibrillationB

目的 研究阵发性心房颤动 (房颤 ,paroxysmalatrialfibrillation ,PAF)能否引起血栓前状态及其原因。方法 用放射免疫学方法对 17例孤立性阵发性房颤患者于房颤发作及终止后 1周测定外周静脉血浆血小板α颗粒膜蛋白 140 (GMP140 )、血栓素B2 (TXB2 )、 6 酮 前列腺素F1α(6 K PGF1α)、TXB2 / 6 K PGF1α和心钠素 (ANP)浓度 ,并与阵发性室上性心动过速 (室上速 ,paroxysmalsuperventriculartachycardia,PSVT)患者及健康对照组相比较。结果 PAF患者房颤发作时红细胞压积 (Hct)、TXB2 、TXB2 / 6 K PGF1α、GMP140、ANP比房颤终止后 1周、室上速、正常对照组明显上升。TXB2 、GMP140、ANP浓度及TXB2 / 6 K PGF1α比值与房颤持续时间呈正相关 ,而与年龄、性别及左心房内径无关。

Objective The aim of this study is to investigate whether paroxysmal atrial fibrillation(PAF)itself can cause prothrombosis state and sought to explore its mechanism.Methods Radioimmunoassay(RIA)was used to measure plasma Granule membrand protein 140(GMP140)?TXB 2?6 K PGF 1α and atrial natriurectic peptide(ANP)levels in 17 patients with lone PAF during AF and 7 days after returnning to sinus rhythm.Levels of these markers were compared to those of the patients with paroxysmal superventricular tachycardia(PSVT)and healthy subjects.Results Patients with PAF had high levels of hematocrit?GMP140?TXB 2?TXB 2/6 K PGF 1α and ANP during AF when compared with patients with PSVT and the healthy subjects.The plasma levels of these markers in patients with PSVT were similar to the levels of healthy subjects and patients with PAF after 7 days of recovery.There were positive correlations between the duration of AF and the levels of these markers except for blood platelet count and hematocrit.But it is not relevant with left atrial size on echocardiography,sex and ages.Conclusion These results indicate that episode of PAF itself enhances platelet activities and hemoconcentration which are influenced by the duration of AF.