鱼油多烯脂酸对血小板聚集和抗凝血作用的实验研究

The Experiment Study of Polyunsaturated Fatty Acids Affecting on Platelet Agglomeration and Anti-coagulation

鱼油多烯脂酸 (Polyunsaturated fatty acids;PU FA)是从鲐鱼 (Chub machrel)鱼油中分离提取的有效成份 ,主要有二十碳五烯酸 (EPA)和二十二碳六烯酸 (DHA) ,实验结果表明 PUFA可明显地抑制由二磷酸腺苷 (ADP)诱导的家兔和大鼠血小板聚集作用。实验也提示 PUFA对小鼠亦有一定的抗凝血作用 ,这些作用均与给药剂量有关。

Polyunsaturated fatty acids (PUFA) was a functional component extracted from fish oil. The experiment results indicate that PUFA might inhibit platelet agglomeration induced by Adenosine diphosphate (ADP) in rabbit and rat. The results also suggested that PUFA has extent effect of anti-coagulation in mice. These effects are related with dosage of giving drug.