摘要
采用高碳酸性缺氧，窒息性缺氧，小鼠抗缺氧及耗氧量同步测定等方法，研究噻拉嗪的抗缺氧作用。结果表明噻拉嗓明显延长缺氧大鼠出现脑皮层电图（ＥＣＯＧ）平坦期时间及心电（ＥＣＧ）消失时间。并延长小鼠心电消失时间。同时证实噻拉嗪有两种作用：（１）降低耗氧量；（２）提高对缺氧的耐受力。微量的噻拉嗪脑室内注射，对小鼠缺氧保护作用显著，并为咪唑克生阻断，提示上述作用与中枢α＿２受体相关。
The effect of xylazine against hypoxia was studied by methods of gypercapnic hypoxia ,asphyxiated hypoxia as well as synchroic measurements of hypoxic extent and oxygen con-sumption in rats and mice. The results showed that xylazine injected ip decreased oxygen consumption. prolonged the maintainance of brain waver ad cardicac wave in hypoxic ratsand mice,enhanced the resistance against hypoxia in rats and mice. Xylazine injected icv intrace protected hypoxic mice reniarkablely, and was blocked by idazoxan. It is suggestedthat these effects are related to central α<sub>2</sub> adrenoceptor.
出处
《江西医学院学报》
CAS
1995年第4期65-69,共5页
Acta Academiae Medicinae Jiangxi
基金
江西省自然科学基金
关键词
噻拉嗪
药理学
脑电描记术
心电描记术
氧消耗
Xylans/pharmacodynamics
electroencephalography
electrocardiography
oxygen consumption
animal.experimental
rats
mice Department Pharmacology,Yichun School of Hygiene,Heilongjiang Department of Pharmacology,Jiangxi Institute of Medical Science and Research
