尼群地平及卡托普利对高血压大鼠糖脂代谢的影响

The Effects of Nitrendipine and Captopril Treatment on Blood Lipid and Sugar Metabolism in Spontaneously Hypertensive Rats

用尼群地平与卡托普利分别治疗１４周龄的自发性高血压大鼠（ＳＨＲ）１４周，治疗期间使两组血压下降水平相当。结果表明：尼群地平治疗ＳＨＲ组较对照ＳＨＲ组血胆固醇及血糖有明显下降，而甘油三酯，高密度脂蛋白，血胰岛素水平无明显改变。卡托普利治疗ＳＨＲ组上述各参数均无明显改变。两种降压药物均不产生血脂及糖代谢的不利影响，尼群地平并有改善作用。

Two groups(12 in each group)of 14-week old spontaneously hypertensive rats(SHR)were treated with nitrendipine(SHRni)and captopril (SHRcp)separately for 14 weeks andthe effects on blood lipid and sugar metabolism were examined and compared with those ofthe controls.The blood pressure levels of two experimental groups were similar during thetreatment.The results showed that SHRni had lower blood cholesterol and sugar than thoseof the agematched control SHR. but similar triglyceride,high density lipoprotein,blood in-sulin;and there was no significant difference in the above mentioned five parameters betweenSHRcp and their controls. It is concluded that Ni and CP have no adverse effects on bloodlipid and sugar metabolism in antihypertensive treatment,and Ni has beneficial effects.