黄芪对Graves病患者T淋巴细胞亚群的影响

The Effect of Huang-Qi on T Lymphocyte Subsets in Graves Disease

用间接免疫荧光法检测３８例Ｇｒａｖｅｓ病（ＧＤ）患者治疗前后Ｔ淋巴细胞亚群的变化。着重观察中药黄芪对其影响。３８例患者Ｔ淋巴细胞亚群皆明显异常；将其对半分成二组：ＧＤ１组单纯口服他巴唑，ＧＤⅡ组服用黄芪加他巴唑。二月后，两组Ｔ＿３、Ｔ＿４值均恢复正常。临床症状基本消失，而Ｔ淋巴细胞亚群在ＧＤ１组改变无显著差异（Ｐ＞０．０５），ＧＤⅡ组则基本恢复正常（Ｐ＜０．０５）。提示黄芪具有免疫调节作用，可提高本病的疗效。

The T lymphocyte subsets were studied in thirty eight cases of Graves disease by indi-rect immiunofluorescence and emphysis was put on the effect of Huang-Qi.T lymphocytesubsets of all the patients were abnormal.The 38 patients were divided into 2 equal groups. One group(GDI)was treated by Tapazole methimazole only,while the other(GDII)byTapazole methimazole and Huang-Qi.After two months,the patients’thyroid function re-covered and clinical symptoms disappeared in both groups.T lymphocyte subsets in GD II al- so recovered(P<0.05)but those in GD Ⅱ did not(P>0.05).It is suggested that Huang-Qiplay an immune regulatory role in patients with Graves disease and that combined therapy ofantithyroid drug with Huang-Qi might be more potent.