鼻腔良恶性肿瘤核仁组成区蛋白的定量研究

Quantitative Study of Nucleolar Organizer Region-associated Proteins in Benign and Malignant Tumours of Nose

对４４例鼻腔良恶性肿瘤进行核仁组成区蛋白（ＡｇＮＯＲ）定量研究。统计学处理结果显示，正常组与乳头状瘤之间核ＡｇＮＯＲ计数无差异（Ｐ＞０．０５），而正常组与恶性肿瘤之间的乳头状瘤与恶性肿瘤之间ＡｇＮＯＲ计数有显著差异（Ｐ＜０．０１），同时恶性肿瘤中不同组织病理学分级之间ＡｇＮＯＲ的计数也有显著差异（Ｐ＜０．０１）。提示ＡｓＮＯＲ定量研究可做为诊断鼻腔良恶性肿瘤、以及恶性肿瘤之间分级的一项新的辅助指标。

Using silver staining technique,nucleolar organizer region-associated proteins(AgNORs)have been studied in paraffin sections of forty four benign and malignant tumoursof nose.The results showed significant difference between the number of AgNORs granulesin thd nuclei of nasal papillomas and those of nasal malignant tumours(P<0.01).Differ-ence was also found among different histopathologic grades of nasal malignant tumours(P<0.01).It is suggested that quantitive study of AgNORs may be used as a new parameter fordistinguishing benign from malignant tumours of nose,and histopathologic grading of nasalmalignant tumorus.