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大肠腺瘤核仁组成区嗜银蛋白的定量研究

A Quantitive Study of Argyrophilic Proteins of Nucleolar Organizer Regions in Colorectal Adenomas
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摘要 用核仁组成区嗜银蛋白(AgNOR)的银染技术研究了57例经内镜切除的大肠腺瘤的AgNOR计数变化,以探讨AgNOR计数评价大肠腺瘤增殖性的价值。结果显示,管状绒毛状大肠腺瘤的AgNOR计数明显高于管状腺瘤,而又明显低于绒毛状腺月(P<0.05);随着腺瘤异型增生的出现和程度的加重,其AgNOR计数逐步增加(P<0.05);随着腺瘤直径的增大,其AgNOR计数亦逐渐递增(P<0.01),且腺瘤的AgNOR计数与其直径呈现有意义的正相关(r=0.38,P<0.025);腺瘤的数目对AgNOR计数无明显影响;位于左半结肠的腺瘤的AgNOR计数高于位于右半结肠的腺瘤(P<0.05)。结果提示AgNOR计数反映了大肠腺瘤的增殖活性,它可作为评价大肠粘膜异型增生的定量参数。 Using argyrophilic proteins of nucleolar organizer regions (AgNOR)silver-staining tech-nique, the AgNOR counts in fifty seven specimens of colorectal adenomas (CA)were exam-ined to investigate their value in assessing the proliferative activity of CA. The AgNORcounts of tubular-villous CA were significantly higher than those in tubular CA, but lowerthan those in villous CA(p<0.05),and increased with the appearance and progression ofdysplasia in CA(p<0.05),as well as with the increase in the diameter of CA(p<0.01)。The AgNOR counts were positively correlated to the diameter of CA (r=0.38, p<0. 025).But the number of CA bore no influence on its AgNOR counts, In addition, the AgNORcounts in the left-sided CA were markedly higher than those in the right-sided CA(P<0.05). These findings suggested that the AgNOR counts may reflect the prolifelative activityof CA. Thus it may be used as a quantitative parameter for the assessment of colorectal mu-cosal dysplasia.
作者 黄群 王崇文
出处 《江西医学院学报》 1994年第3期21-24,F003,共5页 Acta Academiae Medicinae Jiangxi
关键词 银蛋白类 诊断应用 核仁组成区 腺瘤 大肠肿瘤 silver proteins/diagnostic use nucleolus organizer region adenoma intestine,large
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