摘要
应用PNA、UEA、ConA三种生物素化凝集素对30例涎腺肿瘤、8例正常涎腺进行半定量研究。结果显示:①PNA在涎腺肿瘤中的表达增强,且PNA的表达强度与涎腺肿瘤的分化程度相关。恶性肿瘤中的PNA强阳性率为85.7%,高于良性肿瘤(43.8%)和正常涎腺(12.5%);②UEA在涎腺肿瘤中表达减弱,UEA阴性的病例呈侵袭性生长并可发生淋巴结转移,揭示UEA与肿瘤细胞的生物学行为有关。UEA阴性可作为预测涎腺肿瘤转移和复发的一项参考指标。
Thirty cases of salivary tumors have been studiedfor lectin receptorsbyimmunohis-tochemical method using 3 types of biotinated lectins (including PNA , UEA and ConA ).Theresults showed:(1)PNA receptor expression was higher in salivary tumors than that in nor-mal salivary glands and that the degree of expression was related with the degree of tumordifferentiation。 The strongly positive rate in malignant tumors was 85.7%while that in be-nign tumors was 43.8%and in normal salivary glands 12.5%,(2)UEA receptor expressedless in salivary tumors than in normal glands。 Malignant cases with negative UEA grevv in aninfiItrating way and might have lymphnode metastasis. The result indicated that UEA wasassociated with the biological behavior of the tumorcells. UEA negative in malignant casesmight be considered as a reference for prediction of metastasis and recurrence of salivary tu-mors.
出处
《江西医学院学报》
1994年第3期31-33,共3页
Acta Academiae Medicinae Jiangxi