涎腺肿瘤凝集素受体的研究

Study of Lectin Receptors in Salivary Tumors

应用ＰＮＡ、ＵＥＡ、ＣｏｎＡ三种生物素化凝集素对３０例涎腺肿瘤、８例正常涎腺进行半定量研究。结果显示：①ＰＮＡ在涎腺肿瘤中的表达增强，且ＰＮＡ的表达强度与涎腺肿瘤的分化程度相关。恶性肿瘤中的ＰＮＡ强阳性率为８５．７％，高于良性肿瘤（４３．８％）和正常涎腺（１２．５％）；②ＵＥＡ在涎腺肿瘤中表达减弱，ＵＥＡ阴性的病例呈侵袭性生长并可发生淋巴结转移，揭示ＵＥＡ与肿瘤细胞的生物学行为有关。ＵＥＡ阴性可作为预测涎腺肿瘤转移和复发的一项参考指标。

Thirty cases of salivary tumors have been studiedfor lectin receptorsbyimmunohis-tochemical method using 3 types of biotinated lectins (including PNA , UEA and ConA ).Theresults showed:(1)PNA receptor expression was higher in salivary tumors than that in nor-mal salivary glands and that the degree of expression was related with the degree of tumordifferentiation。 The strongly positive rate in malignant tumors was 85.7%while that in be-nign tumors was 43.8%and in normal salivary glands 12.5%,(2)UEA receptor expressedless in salivary tumors than in normal glands。 Malignant cases with negative UEA grevv in aninfiItrating way and might have lymphnode metastasis. The result indicated that UEA wasassociated with the biological behavior of the tumorcells. UEA negative in malignant casesmight be considered as a reference for prediction of metastasis and recurrence of salivary tu-mors.