新疆维吾尔族汉族妇女宫颈糜烂与单纯疱疹病毒活动感染关系探讨

Study on the relationship between the cervical erosion and the herpes simplex virus infection in Xinjiang Uighur and Han nationality women.

目的 探讨新疆维吾尔族 (维族 )、汉族妇女宫颈糜烂与单纯疱疹病毒 (HSV)活动感染的关系。方法 用酶联免疫吸附实验 (ELISA)方法对 79例维族、12 8例汉族不同程度 (Ⅰ、Ⅱ、Ⅲ度 )宫颈糜烂病人和 2 9例维族、41例汉族正常对照进行血清HSV 1型和HSV 2型特异性IgM、IgG抗体检测 ,同时用聚合酶链反应 (PCR)检测上述病例和对照宫颈分泌物中HSV DNA。结果 维、汉族不同程度宫颈糜烂病人HSV 1IgM阳性率 (活动感染率 )分别为 2 7 8%和 2 6 8% ,正常对照维、汉族分别为 2 0 7%和 2 1 9% ,民族间、病例组和正常对照组间以及不同程度糜烂组间HSV 1活动感染率差异无显著 (P >0 0 5 )。维、汉族病例组HSV 2活动感染率分别为36 7%和 32 0 % ,显著高于正常对照组 13 8%和 9 8% (P <0 0 5 ) ,而维、汉族间不同程度糜烂组间差异无显著性 (P >0 0 5 )。维、汉族病例组HSV 2原发感染率为 16 5 %和 13 3% ,宫颈分泌物HSV DNA检出率维、汉族病例组分别为 36 0 %和 31 2 % ,显著高于正常对照组 13 8%和 7 3% (P <0 0 5 )。在病例组中 ,其HSV DNA检出率随糜烂程度的加重而升高。结论 新疆维、汉族妇女宫颈糜烂的产生和HSV 2活动感染有关。

Objective To explore the relationship between the cervical erosion and the herpes simplex virus infection in Xinjiang Uighur and Han women.Methods The serum HSV 1 and HSV 2 specific antibody IgM,IgG were examined by ELISA method in 79 Uighur and 128 Han women who had different degrees of cervical erosion(Ⅰ°、Ⅱ°、Ⅲ°),and 29 Uighur and 41 Han women were as controls,meanwhile the HSV DNA in cervical secretions were also examined by polymerase chain reaction.Results In study group,the positive rates of HSV 1 IgM in Uighur and Han women were 27\^8% and 26\^8% respectively,in control group,it was 20\^7% and 21\^9% respectively.There was no significant difference between the two groups(P>0\^05).The positive rates of HSV 2 in study group(36\^7%,32\^0%)were higher than that in control group(13\^8%,9\^8%),the difference between the two groups was significant(P<0\^01),and the positive rates of HSV DNA of cervical secretion in study group(36\^0%,31\^2%)were also higher than that in control group(13\^8%,7\^3%).The difference was also significant(P<0\^05).Conclusion Xinjiang Uighur and Han women's cervical erosion is associated with the infection of HSV 2.