青光眼小梁切除术并用干扰素的临床疗效观察

Clinical Evaluation of Trabeculae Resection Combined with Interferon for Treatment of Glaucoma

目的 :为评价在青光眼小梁切除术时以不同给药方法并用干扰素后的临床疗效。方法 :将行小梁切除术的 5 2眼随机分成两组 ,一组采用术中干扰素湿棉片敷贴给药 ;另一组于术毕及术后第 3、5、7、14天在滤过区旁结膜下注射干扰素。随访时间9～ 12个月。结果 :( 1)术后第 9～ 12个月 ,结膜下注射组平均眼压为 13 .3± 3 .9mmHg ,术中应用组为 13 .0± 4 .7mmHg。两组无显著差异。 ( 2 )滤过泡形态均以Ⅱ型为主 ,功能性滤过泡在结膜下注射组占 92 .3 % ,术中应用组占 5 7.7%。两组有显著差异。 ( 3 )两组主要并发症为短暂性角膜上皮缺损。结论 :青光眼小梁切除术并用干扰素能有效改善滤过功能 ,提高手术成功率。

Objective: To investigate the therapeutic efficacy of different meth ods of administering interferon for patients underwent trabeculae resection. Methods: 52 eyes undergone trabeculae resection in glaucoma clinic were divided into 2 groups randomly: one was applied a piece of sponge soaked by interferon intraoperatively; in the other group, interferon were subconjunctivally injected near the filtering bleb intraoperatively and on the 3rd,5th,7th and 14th postop erative day. The time of follow-up was 9-12 months. Results: (1) The mean intraocular pressure (IOP) achieved in the subconjunctival group was 13.3±3.9mmHg on the po stoperative 9-12 month, while 13.0±4.7mmHg in the intraoperative interferon gro up. No significant difference existed between the two groups . (2)Most of the filtering blebs was type Ⅱ. There were 92.3% functional ble bs in the subconjunctival group, while 57.7% in the intraoperative interferon gr oup. There was significant difference between the two groups. (3) The main compl ication in both two groups was transient corneal epithelium defect. Conclusion: Application of interferon after the trabeculectomy can improve the filtering function and enhance the success rate. The efficacy of the postoperative subconjunct ival group was better than that of the intraoperative application group.