胃癌血清胃泌素含量升高的原因分析

Analyse the reasons of high level of serum gastrin in gastric cancer.

目的 研究胃癌病人血清胃泌素 (Gs)含量升高的原因。方法 应用放免法测定胃癌病人血清Gs含量 ,并分析其与胃癌发生部位、临床病理分期、预后的关系以及手术前后血清Gs的变化。结果 胃底贲门癌病人血清Gs值明显升高 ,而胃窦癌、胃体癌血清Gs值与正常对照组接近 ;随着胃癌临床病理分期的进展 ,血清Gs含量逐渐升高 ;胃癌术后 2周血清Gs含量虽明显下降 ,但术后 3个月恢复到与术前水平相当 ;对 41例不能手术切除的胃癌病人进行随访 ,发现生存期超过 1年者血清Gs含量与生存期未超过 1年者接近。结论 胃癌病人血清Gs升高是一种继发性改变 ,不能作为一种肿瘤标志物 。

Objective To study the reasons of high level of serum gastrin in gastric cancer.Methods The contents of serum gastrin were determined by using radioimmunoassay.We analysed the relationship between the serum gastrin contents and the site,clinical pathological stages and the prognosis of gastric cancer,and the values of serum gastrin in the pre-and post-operation.Results The values of serum gastrin increased markedly in the neoplasma of cardia and fundus,but was same in the neoplasma of antrum and gastric body as the normal persons.With the development of clinical pathological stages,the values of serum gastrin increased gradually.Although the values of serum gastrin decreased on the second week after the operation,it returned to the pre-operation level on the third month after the operation.As for the follow-up result of 41 cases of unresectable gastric cancer,the serum gastrin values was the same in those surviving more than or less than 1 year.Conclusion The high level of serum gastrin is a secondary change,it’s neither a tumor marker nor a prognostic factor.