奥曲肽预防ERCP术后胰腺炎的疗效

Preventive effect of octreotide on pancreatitis after ERCP

目的 探讨奥曲肽对内镜逆行胰胆管造影 (ERCP)术后高淀粉酶血症及急性胰腺炎的预防作用。 方法 行ERCP患者共 1 3 2例 ,随机分为两组 :预防组 67例 ,分别于术前 3 0min及术后 2 4hq8h皮下注射奥曲肽 0 .1mg;对照组 65例 ,术前、术后不用奥曲肽注射。术前、术后 3h及 2 4h检测血清淀粉酶 ,同时观察腹痛及胰腺炎的发生情况。 结果 预防组ERCP术后血淀粉酶分别是 2 96.2 4± 2 73 .71IU/L和 3 55.61± 3 1 8.66IU/L,明显低于对照组 ( 594 .96± 562 .73IU/L和 651 .1 9±53 4 .84IU/L,P <0 .0 1 )。预防组发生急性胰腺炎 1例 ( 1 .4 9% ) ,对照组发生 5例 ( 7.69% ,P <0 .0 1 )。 结论 奥曲肽能有效预防ER

Objective To investigate the preventive effect of octreotide on acute pancreatitis and hyperamylasemia after ERCP. Methods 132 patients who underwent ERCP were divided randomly into 2 groups:the preventive group was received octreotide 0.1mg,30minutes before and 24 hour q8h after ERCP respectively;the control group received nothing.The mean concentration of serum amylase at 3h and 24h after ERCP was measured in all patients,and the positive rates of abdominal pain and pancreatitis after ERCP were observed. Results The mean concentration of serum amylase (IU/L)at 3h and 24h post ERCP was 296.24±273.71 and 355.61±318.66 in the preventive group ,and 594.96±562.73 and 651.19±534.84 in the control group (P<0.01).Acute pancreatitis was occurred in 5 cases (7.69%)of the control group and in 1 cases ( 1.49 %) of preventive group after ERCP(P<0.01). Conclusion Octreotide can prevent effectively hyperamylasemia and acute pancreatitis after ERCP.