摘要
目的:探讨尿中血管内皮生长因子(VEGF)表达与膀胱移行细胞癌的关系,以及尿VEGF做为瘤标的价值。方法:用抗体夹心ELISA法测量58例研究对象的尿VEGF,并与尿细胞学检查比较(双盲法)。其中28例为膀胱移行细胞癌,每3个月随访1次,6例复发。结果:尿VEGF在膀胱癌组高于非膀胱癌组(P<0.001);G1级癌分别低于G2、G3级癌(P<0.05),在早期复发组高于未复发组(术前)(P<0.05),尿VEGF诊断实验的特异度和灵敏度分别为93.3%、85.7%。结论:尿VEGF水平可反映膀胱癌的预后、复发;尿VEGF做为诊断和术后监测瘤标有较高价值,优于尿细胞学检查。
Objective Urinary vascular endothelial growth factor (VEGF) and its correlastion with bladder transitional cell carcinoma (BTCC) was studied and its value to be a tumor marker for detection and postoperative surveillance of BTCC was assessed. Methods VEGF was measured by quantitative sandwich enzyme-linked immunosorbent assay (ELISA) in the urine of a total of 58 study subjects.and was compared directly with the cytologic effect (Double-blind method). Twenty-two cases of BTCC had postoperative surveillance every 3 months.and 6 cases relapsed. Results The urinary VEGF was higher in the patients with BTCC than the others without BTCC (P<0.001). There was significance between G1 and G2 (P<0.001) or G1 and G3 (P<0.001). The mean urinary VEGF expression in the recurred patients was higher than that of unrecurred patients (P<0.05). The sensitivity and specificity of urinary VEGF for diagnosing BTCC were 85.7%,93.3% respectively. Conclusion VEGF is higher in the urine of patients with BTCC and is correlated with the prognosis and recurrence of BTCC. As a tumor marker for detection and surveillance of BTCC.urinary VEGF is of greater value than cytology.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2001年第6期454-457,共4页
Chinese Journal of Clinical Oncology