婴幼儿毛细支气管炎血中TXB_2、6－Keto－PGF_（1α）变化的研究

A Study on Changes in Blood Thromboxane B_2(TXB_2)and 6-Keto-Prostaglandin Fla(6-Keto-PGF_(1α))in Infantile Bronchiolitis

应用放射免疫分析法对２０例正常儿、２７例毛细支气管炎、７例肺炎和６例上感进行血浆血栓素Ｂ＿２（ＴＸＢ＿２），６－酮－前列素Ｆ＿（１α）（６－Ｋｅｔｏ－ＰＧＦ＿（１α））测定，动态观察其变化。结果显示：（１）毛细支气管炎急性期ＴＸＢ＿２、ＴＸＢ＿２／６－Ｋｅｔｏ－ＰＧＦ＿（１α）（Ｔ／Ｋ）比值明显升高，病情重者较高，恢复期则下降至正常，而６－Ｋｅｔｏ－ＰＧＦ＿（１α）无显著变化；（２）肺炎或上感上述指标均无显著变化。提示ＴＸＡ＿２－ＰＧＩ＿２之间平衡失调可能是毛细支气管炎发病的重要因素之一。

The levels of blood TXB_2 and 6-Kcto-PGF_(1α) were determined by radioimmunoassay.Blood was obtained fromtwenty normal infants,27 patients with bronchiolitis,7 with pneu-monia,and 6 with upper respiratory infection(URI).The results were as follows:(1)Thelevel of TXB_2 and ratio of TXB_2/6-Keto-PGF_(1α)(T/K)in patients with buonchiolitis were sig-nificantly higher than those in normal subjects and lowered with improvement of the disease,while the oevel of 6-Keto-PGF_(1α) remained unchanged.(2)There was no significant changeim the above indices between patients with either pneumonia or URI and normal subjects.Itis suggested that TXA_2-PGI_2 imbalance isan important factor participating in the pathogene-sis of bronchiolitis.