血清甲胎蛋白阴性或低值大肝癌组织病理学和免疫组化观察

Histopathology and Immunohistochemistry of Large HCC with Negative or Low Level Serum AFP

观察了３０例血清甲胎蛋白阴性或低值大肝癌的组织病理学和免疫组化学。发现有１９例透明细胞型肝细胞癌，其中仅２例免疫组化试验甲胎蛋白阳性。此结果提示在肝细胞癌细胞内发生的透明变可抑制甲胎蛋白合成，这可能是导致大肝癌患者血清甲胎蛋白阴性或低值的因素之一。

Histopathology and immunohistochemistry of 30 cases of large hepatocellular carcinoma(LHCC)with serum alpha fetoprotein(AFP)negative or low level were observed.It wasfound that there were 19 cases(19/30)of clear cell type HCC,of which AFP was present inonly 2 cases examined immunohistochemically. The result suggests that clear changes withinHCC cells may inhibit synthesis of AFP in these cells.This might be one of the factors caus-ing negative or low level serum AFP in patients with LHCC.