摘要
AIM The purpose is to lay a theoretical foundation for the development of L Ψ ephedrine hydrochloride as a novel drug. METHODS L Ψ ephedrine and its hydrochloride were acquired by purifying and recrystallizing crude products prepared using enzyme engineering techniques. Their structural and chemical properties were analyzed by TLC, DSC, IR, UV, EIMS m/z , optical activity and elementary analysis.RESULTS The average yield and purity of refined L Ψ ephedrine were 65.0% and 99.96%, and those of L Ψ ephedrine hydrochloride were 83.3% and 99.8%, respectively. Instrumental analysis showed that all of their tested properties and structural were consistent with the theoretical data. CONCLUSION L Ψ ephedrine and its hydrochloride with high purity were obtained and their properties were confirmed.
AIM The purpose is to lay a theoretical foundation for the development of L Ψ ephedrine hydrochloride as a novel drug. METHODS L Ψ ephedrine and its hydrochloride were acquired by purifying and recrystallizing crude products prepared using enzyme engineering techniques. Their structural and chemical properties were analyzed by TLC, DSC, IR, UV, EIMS m/z , optical activity and elementary analysis.RESULTS The average yield and purity of refined L Ψ ephedrine were 65.0% and 99.96%, and those of L Ψ ephedrine hydrochloride were 83.3% and 99.8%, respectively. Instrumental analysis showed that all of their tested properties and structural were consistent with the theoretical data. CONCLUSION L Ψ ephedrine and its hydrochloride with high purity were obtained and their properties were confirmed.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2001年第5期398-400,共3页
Journal of China Pharmaceutical University
基金
国家"九五"重点科技攻关 ( JB0 2 -96 -90 2 -0 3-0 7)资助专题
