运动对糖尿病大鼠血清瘦素水平的影响

Effects of exercise on concentration of serum leptin in diabetic rats

目的 探讨运动与血清瘦素水平的关系，观察不同运动量对糖尿病大鼠体质量、血糖、血清胰岛素和血清瘦素的影响． 方法 将动物分成６组，分别为正常对照组、正常运动组、糖尿病组、糖尿病小运动量组、糖尿病中运动量组和糖尿病大运动量组．运动组按Ｐｌｏｕｇ方法进行游泳训练．结果 正常运动组大鼠游泳８周后的血清瘦素浓度较运动前显著降低， 运动前４个组的糖尿病组大鼠与正常对照组相比，体质量、血清胰岛素和血清瘦素水平显著降低，血糖浓度显著升高．游泳８周后只有糖尿病中运动量组大鼠的每周体质量增加数明显回升，血糖浓度较运动前降低３５％，血清胰岛素浓度较运动前升高３８％．血清瘦素浓度较运动前升高 ４０％，而糖尿病小运动量组和糖尿病大运动量组大鼠运动 ８周后的 上述指标与运动前相比无显著变化， 多元相关回归分析，仅提示糖尿病大鼠血清胰岛素是血清瘦素有意义的影响因素。结论 正常生理状态下运动降低血清瘦素水平是机体为维持自身体质量稳定和能量平衡的一种适应性反应；而在链脲佐菌素（ｓｔｒｅｐｔｏｚｏｔｏｃｉｎ，ＳＴＺ）糖尿病状态下 ，瘦素似乎与胰岛素关系更密切，中等强度运动在降低血糖，改善机体对胰岛素敏感性的同时，似乎也改善了对瘦素的敏感性；运动量不足或?

Objective To study if exercise can affect serum leptin level that related with body weight regulation and observe the influence of different exercise intensity on body weight, blood glucose, serum insulin and leptin in streptozotocin(STZ) diabetic rats. Methods Six experimental groups of rats were investigated: normal controls (NC ), normal exercise (NE ), diabetic group (DG), low-intensity exercise diabetie group (LEG), medium-intensity and great-intensity exercise group (MEG and GEG. Swimming is trained according to Plog metheds. Results After 8-week swimming, serum leptin concentration of NE markedly decreased. Before swimming, body weight, serum insulin and leptin level of all the STZ diabetic rats were significantly lower than that of NC, and blood glucose were higher. Eight weeks later, only the rals of MEG increased obviously in body weight weekly, and concentration of blood glucose decreased 35%, serum insulin level increased 38%, serum leptin level increased 40% respectively compared with that before excercise. However, 8 weeks later the above indexes in LEG and GEG showed no significant differences with those of pre-exercise. Multiple relation and stepwise regression;anatysis were applied, indicating that in diabetic rats only serum insulin was a significant influencing factor of serum leptin. Conclusions Under normal physiological condition decreased serum leptin leve1 by exercise is an adaptive reaction to maintain stable body weight and to balance energy, while under STZ diabetic condition, leptin seems to be closely related with insulin. Middle-intensity exercises reduce blood glucose and improve insulin sensitivity, at the same time it seems to have improved leptin sensitivity. Insufficient exercises or excessive exercises have no obvious therapeutic effect on diabetes.