弹力酶诱发动脉瘤模型

Aneurysmal Model Induced by Elastase

目的以猪胰弹性蛋白酶腐蚀动脉壁结构,建立动脉瘤模型,以期获得形态和病理均与临床颅内动脉瘤相似的模型。方法选用新西兰大白兔,将猪胰弹性蛋白酶处理过的兔一侧颈动脉段移植到对侧正常颈动脉侧壁形成动脉瘤模型。在2周～1个月内对动脉瘤模型进行复查,并行病理学检查。结果移植酶处理的动脉段形成的动脉瘤模型在1个月内保持稳定或略有增大,动脉瘤壁呈紫红色,容易破裂,弹力板缺失,只由薄层的结缔组织构成。结论移植酶处理的动脉段形成的动脉瘤模型手术操作简单,重复性好,模型稳定,具有良好的形态和病理特征,有望取代流行的静脉移植动脉瘤模型。

Objective To induce the aneurysms by corrosion of aneurysmal wall with elastase,inithting clinical intracranial aneurysms patho-morhologically.Methods The elastase-corroded arterial segments were transplanted onto lateral walls of carotid arteries.Follow-up and pathological examination of the aneurysms were made at two weeks and one month after construction.Results The aneurysms formed by the transplantation of elastase-corroded arterial segments were found persistent or enlarge a little within one month.The aneurysms were purplish red and easy to rupture when exposed.The walls were deprived of elastic layer,and constructed by thin connective tissue.Conclusions The aneurysm s made by transplanting elastase-corroded arterial segments are simple to built,while morphological and pathological characteristics are demonstrated good clinical mimicry,we believe our ameu rysm model may well substitute the most popularly used aneurysms made of venous porches.