西比灵治疗脑梗塞的TCD及血流变研究及临床疗效观察

A CLINICAL EFFECT OF FLUNRIZINE IN TREATMENT OF CEREBRAL INFARCTION OBSERVED BY THE CHANGES OF TCD AND CBF

本文研究西比灵治疗脑梗塞的脑血流及血流变学变化及临床疗效。采用经颅多普勒超声 (TCD)诊断技术及血流变指标检测 ,对 36例脑梗塞患者服用西比灵前后变化及临床疗效进行观察 ,并与对照组相比较。TCD结果显示西比灵治疗后颅内动脉血流速度明显增快 ;血流变各项指标有一定程度降低 ;神经功能评分减少值显著提高 ,生活能力明显改善 ,临床总有效率达 86 11%。表明西比灵能改善脑梗塞患者的脑部供血、供氧 ,降低血粘度 ,改善微循环 ,保护脑组织。

The clinical effect of flunarizine(Sibelium)trestment in acute cerebral infarction patiants were investigated by using transcranial dopple(TCD)and cerebral blood flow(CBF). The resulte showed that the CBF was increased and blood viscosity was decreased after treatment which compared with control group(P<0.05),neurological deficit and life quality were improved significantly.We conclude that calcium channel blocking agent flunarizine can protect the brain cell,reduce blood viscosity and improve life quality.It is safety and convenient in CVD patients and is worthy of populize.