肝毒性中药及其与药性和有效成分的关系——对55种中药肝毒性文献资料的分析报告

The relationship between Herbs with hepatotoxicity and its property and active components ——Analysis of literature on hepatotoxicity of 55 kinds herbs

目的 :研究有关文献资料中中药肝毒性的报告及其与四气、五味、归经、有效成分之间的关系。方法 :应用文献研究方法 ,对 55种具有肝毒性的中药进行统计归类分析研究。结果 :中药四气、五味、归经及其有效成分与肝毒性有一定相关性。肝毒性主要集中在寒、热类 ,苦、辛类 ,归肝、脾、肾经类和有效成分中碱、甙类药物方面。结论 :中药药性理论及有效成分均与肝毒性有一定的关系 ,应用归类分析的方法对文献资料进行分析研究是中药毒性研究中确实可行的方法。

objective: Study the reports on the hepatotoxicity(HTX) of herbs in certain literature and the relation between the HTX and four characters(FC), five tastes(FT), channel distributions(CD) and active components(AC) of herbs. Methods: Applying literature statistic method, add up, classify and analyze 55 herbs with HTX. Results: There are certain relation between FC, FT, CD and AC of herbs, and HTX. HTX mainly occurs among the herbs that are cold or heat in property, bitter or acrid in taste, distribute to liver, spleen or kidney channel and their AC including alkaloids, glycosides, etc. Conclusions: There exists some relation between herbs property and HTX. To study and analyze the harm of herbs with literature statistics method is feasible.