鼻咽癌治疗前后TSGF的测定及其意义

The clinical value of the TSGF pre and post-therapy in patients with nasopharygeal carcinoma(NPC)

目的 :检测鼻咽癌患者治疗前后血恶性肿瘤相关物质群 (TSGF)的水平 ,探讨 TSGF在鼻咽癌的早期诊断及预后判断的意义。方法 :动态观察 35例鼻咽癌患者在治疗前、后 TSGF水平与 EBV滴度的变化 ,并分析两者之间的关系。结果 :TSGF与 EBV- Ig A的诊断阳性率分别为 91% ,97%。两者之间无相关性。治疗无效者TSGF保持在较高水平 ,有效者则显著下降。结论 :TSGF可作为鼻咽癌早期诊断的血清肿瘤标志物之一 ,动态监测对于了解病情变化有重要临床意义。

Objective:To investigate the role of TSGF (tumor supplied group of factor) in early diagnosing and predicting in patients with NPC.Method:EBV IgA and level of TSGF were measured before therapy and 1 month,1 year after therapy in 35 patients with NPC,and the relationship between them was researched.Result:The diagnostic sensitivity of TSGF and EBV IgA was 91%,97% respectively,there is no significant relation between them.After treatment,the level of TSGF in PD (progression disease) patient remained higher,but had a significantly drop in RR(includine the CR?PR and SD) patient.Conclusion:Results suggested that TSGF may be useful in diagnosing and prediction of NPC.