子宫内膜增生与高分化宫内膜样腺癌葡萄糖转运蛋白1型表达及其鉴别诊断意义

Expression of Glucose Transporter-1 in Endometrial Hyperplasia and Well- Differentiated Endometrioid Adenocarcinoma

目的 葡萄糖转运蛋白1型（GLUT1）在子宫内膜增生及高分化宫内膜样腺癌组织中的表达及其鉴别诊断意义。方法 收集60例刮宫标本，包括诊断明确的各种类型内膜增生和高分化宫内膜样腺癌，采用单克隆抗体GLUT1的免疫组化SP方法进行染色。结果 不伴有非典型性的单纯性增生（12例）和复杂性增生（7例）的内膜组织分别只有2例和1例局灶化生细胞表达GLUT1；13例复杂性非典型增生全部呈不同程度的GLUT1阳性表达；28例高分化宫内膜样腺癌中，26 例GLUT1异常表达。结论 GLUT1异常表达是宫内膜非典型增生和宫内膜样腺癌的特征性生化改变，免疫组化检测GLUT1表达有助于鉴别宫内膜增生与非典型增生。

Objective To investigate the expression of glucose transporter-1（GLUT1）in endometrial hyper- plasia and well-differentiated endometrioid adenocarcinomas． Methods Sixty formalin fixed, paraffin- embedded sections of various endometrial hyperplasia and well-differentiated endometrioid adenocarcino- mas were immunostained with rabbit anti-GLUT1 antibody using streptavidin-biotin method． Results Two of 12 simple hyperlasia and one of seven complex hyperplasia without atypia were focally positive in metaplastic epithelia． All complex atypical hyperplasia showed positive in varied degree, and 26 among 28 cases of adenocarcinoma were stained positively． Conclusions Overexpression of GLUT1 is a consistent feature of atypical hyperplasia and adenocarcinoma． GLUT1 immunostaining is found to be helpful in distingushing hyperplasia with atypia from those without atypia．