二甲基甲酰胺生物接触限值的研究

Studies on biological exposure indices of dimethylformamide

目的 探讨我国二甲基甲酰胺 (DMF)的生物接触限值 (BEI)。方法 实验室建立“车间空气中的DMF”、“尿中甲基甲酰胺 (NMF)”气相色谱的监测方法 ,对浙江省某腈纶厂接触DMF作业现场进行劳动卫生学调查及车间空气中DMF浓度与班末尿中NMF含量相关性研究 ,动态观察职业接触者尿中NMF排泄量。结果 DMF接触者尿中NMF浓度与车间空气中的DMF浓度有密切正相关(^Y=0 .2 96X -0 .2 41,r=0 .984,P =0 .0 1) ,脱离接触后尿中NMF衰减方程为 Y =3 .70 4e- 0 .32 3t ,排出速率常数平均为 - 0 .32 /h ,半排期为 1.2 9h。当尿中NMF≥ 10mg/gCr时 ,肝生化指标异常率为 5 0 .0 % ;当尿中NMF <10mg/gCr时 ,与对照组比较 ,肝生化指标差异无显著性 (P >0 .0 5 )。结论 DMF接触者BEI:班末尿中NMF为 10mg/gCr。

Objective To explore the biological exposure indices(BEI) of dimethylformamide(DMF) in China. Methods Examination methods of DMF in workshop air and N methylformamide(NMF) in urine were established by gas chromatograph in lab.A dynamic observation on NMF excrement in urine of exposure workers was made through labor hygiene inspection in the DMF exposure location of a nylon factory in Zhejiang Province.And the relative research on the concentration of DMF in workshop air with the concentration of NMF in the shift end urine. Results The concentration of NMF in urine of DMF exposure had close positive relation to DMF concentration in workshop air( =0.296 X -0.241, r =0.984, P =0.01).After exposure,the attenuation equation of the concentration of NMF in urine is Y =3.703 9 e -0.322 7 t while the constant excretion rate was -0.32/h and half excretion time was 1.29 hours.When the concentration of NMF in urine was ≥10 mg/g Cr,the indices of liver biochemistry abnormal rate was 50.0%.Compared with control groups,when the concentration of NMF in urine was less than 10 mg/g Cr,the indices of liver biochemistry shows no significant difference( P >0.05). Conclusion BEI of DMF exposure the concentration of NMF in urine of shift end is 10 mg/g Cr.