聚膦腈/聚酸酐共混物的相容性和水解行为

COMPATIBILITY AND DEGRADATION OF NOVEL POLYPHOSPHAZENE/ POLYANHYDRIDE BLENDS

采用溶液混合法制备了聚 [(双 甘氨酸乙酯 )膦腈 ](PGP)与聚酸酐 (PSA或PSTP)的共聚物 .利用示差扫描量热仪和相差显微镜研究了两体系的共混相容性 ,发现PGP与PSTP具有部分相容性 .体外降解试验表明 ,PGP PSTP降解行为呈均一性 ,且由于PSTP酸性产物的催化作用 ,降解速度明显较PGP加快 (约 15天 )并随PSTP含量增加而加快 .PGP

Poly[bis(glycine ethyl ester) phosphazene] was blended with polyanhydride (PSA or PSTP) in various ratios using solvent-mixing technique. The compatibility of these blends was evaluated by DSC and contrast microscopy method. The results showed that PGP was partially compatible with PSTP. In vitro degradation experiment was conducted in distilled water at 37 degreesC. The degradation behavior of PGP/PSTP blends exhibited homogenious. Furthermore, the degradation rate was much faster than that of PGP and could be regulated by adjusting PSTP content due to the catalyze effect of acidic products of PSTP. PGP/PSTP blends could be a series of potential biomaterials for drug controlled release.