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共刺激分子CD28/CTLA-4-B7与1型糖尿病 被引量：1

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摘要 CD2 8/细胞毒性T淋巴细胞相关抗原 (CTLA) 4与B7的相互作用是T细胞活化的重要调节因子 ,在自身免疫性疾病的发生、发展中起着不同的作用。其中 ,CD2 8 B7的过度表达是自身免疫性 1型糖尿病发生的重要原因之一 ;而CTLA4可使CD2 8 B7共刺激信号中止 ,是T淋巴细胞活化的负性调节信号。因此 ,运用B7单克隆抗体阻断CD2 8 B7通路或通过加强B7 CTLA 4作用来抑制自身免疫活性T细胞 ,有可能成为治疗该病的新手段。
作者 施毕旻
机构地区 苏州大学生物技术研究所
出处 《国外医学（内分泌学分册）》 2001年第5期239-241,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 1型糖尿病 共刺激分子 CD28/CTLA-4-B7
分类号 R587.1 [医药卫生—内分泌]
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参考文献10

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同被引文献18

  • 1孙逸平.Ⅰ型糖尿病和HLA的关联[A]..1999 WHO DLAMOND计划(北京)国际研讨会文集[D].,1999.70-81.
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  • 7De Valck D,Jin DY,Heyninck K,et al.The zine finger proteinA20 interacts with a novel anti-apoptonic protein which is cleaved by specific caspases.Oncogene,1999,18:4182-4190.
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国外医学（内分泌学分册）
2001年 第5期

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