期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

浆细胞膜糖蛋白PC-1与胰岛素抵抗 被引量：3

下载PDF
导出
摘要 浆细胞膜糖蛋白 1 (PC 1 )属 2型膜结合糖蛋白 ,分布于体内多种细胞上。在胰岛素抵抗或 2型糖尿病的人或动物中均发现PC 1的含量增高伴胰岛素受体酪氨酸激酶活性的下降及自动磷酸化作用的降低 ,从而抑制了胰岛素的作用 ,导致胰岛素抵抗。其抑制作用位点可能位于受体或受体后。部分实验证实PC 1对胰岛素的抑制作用与PC 1基因突变或多态性有关 ,提示可通过应用PC 1的单克隆抗体或二甲双胍来降低PC 1含量或阻碍PC 1与胰岛素受体相互作用 ,治疗部分胰岛素抵抗的病人。
作者 徐梅 司元国 董砚虎
机构地区 山东大学齐鲁医院内分泌科 青岛市内分泌糖尿病研究所
出处 《国外医学（内分泌学分册）》 2001年第5期244-246,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 浆细胞膜糖蛋白-1 胰岛素抵抗 胰岛素受体酷氨酸激酶
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献13

  • 1Sakoda H,Ogihara T,Anai M,et al.No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes [J].Diabetes,1999,48:1365-1371.
  • 2Stefan C,Wera S,Stalmans W,et al.The inhibition of the insulin receptor by the membrane protein PC-1 is not specific and results from hydrolysis of ATP [J].Diabetes,1996,45:980-983.
  • 3Youngren J F,Maddux B A,Sasson S,et al.Skeletal muscle content of membrane glycoprotein PC-1 in obesity [J].Diabetes,1996,45:1324-1328.
  • 4Frittitta L,Camastra S,Baratta R,et al.A soluble PC-1 circulates in human plasma:relationship with insulin resistance and associated abnormalities [J].J Clin Endocrinol Metab,1999,84:3620-3625.
  • 5Maddux B A,Goldfine I D.Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor α-subunit [J].Diabetes,2000,49:13-19.
  • 6Frittitta L,Youngren J,Vigneri R,et al.PC-1 content in skeletal muscle of non-obese,non-diabetic subjects:relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity [J].Diabetologia,1996,39:1190-1195.
  • 7Frittitta L,Spampinato D,Solini A,et al.Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects [J].Diabetes,1998,47:1095-1110.
  • 8Belfiore A,Costantino A,Frasca F,et al.Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity [J].Mol Endocrinol,1996,10:1318-1326.
  • 9Kumakura S,Maddux B A,Sung C K.Overexpression of membrane glycoprotein PC-1 can influence insulin action at a post-receptor site[J].J Cell Biochem,1998,68:366-377.
  • 10Whitehead J P,Humphreys P J,Dib K,et al.Expression of the putative inhibition of the insulin receptor tyrosine kinase PC-1 in dermal fibroblasts from patients with syndromes of severe insulin resistence[J].Clin Endocrinol(Oxf),1997,47:65-70.

同被引文献48

  • 1于永春,李智,李晶华,滕小洪,汪纯,赵敏.PC-1基因K121Q变异与2型糖尿病的关系[J].检验医学,2005,20(4):313-316. 被引量：5
  • 2Costanzo BV,Trischitta V,Paola RD,et al. The Q allele variant(Gin 121) of membrane glycoprotein PC- 1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (Lysl21) [J]. Diabetes, 2001, 50 (4) : 831-836.
  • 3Pizzuti A, Frittitta L, Argiolas A,et al. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance[J]. Diabetes, 1999,48(9) : 1881-1884.
  • 4Kubaszek A, Pihlajamaki J, Karhapaa P, et al. The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia[J]. Diabetes Care, 2003,26 (2) : 464-467.
  • 5Frittitta L,Baratta R ,Spampinato D. The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance[J]. Clin Endocrinol Metab,2001,86(12):5888-5891.
  • 6Simonetta B,Ornella L,Sabrina P,et al. The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction[J]. Diabetes,2005,54(10) :3021-3024.
  • 7Rasmussen SK, Urhammer SA, Pizzuti A, et al. The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians [J]. Diabetes, 2000, 49 (9) :1608- 1611.
  • 8Marre M, Jeunemaitre X, Gallosis Y,et al. Contribu- tion of genetic polymorphism in the rennin angiotension system to the development to frenal complications in insulin-dependent diabetes. Gene diba study group[J], J Clin Invest, 1997,99 (7) : 1587-1589.
  • 9Heieh MC,Lin SR,Hsieh TJ,et al. Increased frequency of angiotensin-converting enzyme DD genotype in patients with type 2 diabetes in Taiwan [J]. Nephrol Dial Transplant,2000,15(7) : 1006-1008.
  • 10Wong TY, Chan JC, Poon E. Lack of association of angiotensin-converting enzyme (DD/Ⅱ) and angiotensinogen of gene polymorphism with renal function among Chinese patients with type 2 diabetes[J]. Am J Kidney Dis, 1999,33 : 1064-1066.

引证文献3

二级引证文献9

国外医学（内分泌学分册）
2001年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部