血液高凝状态加重糖尿病肾病肾功能障碍

Hypercoagulation aggravates renal dysfunction in patient with diabetic nephropathy

目的 探讨糖尿病肾病患者血液高凝状态与肾功能的关系。方法 46例伴有肾病综合征的糖尿病肾病患者 ,以 2 4h内生肌酐清除率分为高 (H)、中 (M)和低 (L)三组 ,并对其中 14例实施华法林治疗。系统检测凝血、纤溶及肾功能指标。结果 伴随肾病进展 ,凝血活性进一步亢进 ;华法林治疗改善高凝状态后 ,可降低肾病恶化速度。结论 血液高凝状态是糖尿病肾病患者肾功能障碍的原因之一。

Objective To investigate the relationship of hypercoagulation and renal dysfunction in patients with diabetic nephropathy(DN). Methods Forty six diabetes type Ⅱ patients with nephrotic syndrome were divided into 3 groups according to 24 hr creatinine clearance (Ccr) as high, middle and low groups. Fourteen of the 46 patients received warfarin therapy. The parameters of coagulation and fibrolysis as well as renal function were examined. Results Patients with moderate and major renal dysfunction (M group and L group) displayed higher activities of coagulation than those with mild renal dysfunction (H group) did. Warfarin could obviously improve the status of coagulation and fibrolysis in patients with DN and delay the progress of renal dysfunction. Conclusion Hypercoa gulation was one of the causes of renal dysfunction in patients with DN.